雷平生的研究領域及研究成果
研究組目前進行的主要研究：具有特定生物活性的天然產物配糖體合成、結構修飾與構效關系研究：研究組還進行具有抗耐藥菌活性的新型大環內酯抗生素藥物研究。
主持與參與多項國家科技部研究項目、國家自然基金與北京市自然基金研究項目，承擔國家教育部天然產物資源重點試驗室有機合成研究組研究項目。
主持協和醫科大學研究生高等有機化學課程，同時擔任立體化學，不對稱合成，有機反應等課程授課工作。已培養博士研究生、碩士研究生多名。
雷平生研究員在國內外專業雜誌上發表研究論文50余篇。
近年來(2000-2009)發表的部分研究論文擇錄如下：
1.Peng Xu, Lu Liu, Xiao-zhuo Chen, Yun Li, Jian Liu, Zhi-ping Jin, Guang-qiang Wang,
Ping-sheng Lei*
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl
side chains and their antibacterial activity
Bioorg. Med. Chem. Lett. 2009 19（15）
2. Haixing Wang, Fuqin Su, Liang Zhou, Xiaoguang Chen, Pingsheng Lei*
Synthesis and cytotoxicities of icogenin analogues with disaccharide residues
Bioorg. Med. Chem. Lett. 2009 19（10）
3. Peng Xu, Lu Liu, Zhi-ping Jin，Guang-qiang Wang,Jian Liu,Yu Li,Ping-sheng Lei *
Synthesis snd Antibacterial Activity of 4”-O-heteroarylcarbamoyl Derivatives of
Macrolide Bioorg.Med.Chem.Lett. 2008 18
4. Lu Liu, Peng Xu, Lei Ping-sheng*
Synthesis of Derivatives of imidazo[4,5-b]pyridine: Novel sulfur contained Side Chains for macrolide antibiotics Chinese Chemical Letters 2008 19（1） 1-4
5. Peng Xu, Lu Liu, Zhiping Jin and Lei Ping-sheng*
Synthesis snd Antibacterial Activity of Derivatives of 6-O-allylic Acylides
Bioorg.Med.Chem.Lett. 2007 17
6. Shu Jie-hou, Liang Zhou, Ping Sheng Lei*, De Quan Yu
Synthesis of Two Derivatives of Tigogenyl Disaccharides Containing N-acetylglucosamine and the Long Range Shielding Effect of Benzoyle Group
Chinese Chemical Letters, 2007, 18（2）
7. Liang Zhou, Hou Shu-jie, Xu Peng, , Dequan Yu, Lei Ping-sheng*,
Synthesis and Antitumor Activities of 26-O-tert-Butyldimthylsoliyl Protodisogenyl β-D-Glucopyranoside
Chinese Chemical Letters, 2006, 17（5）
8. Hou Shu-jie, Xu Peng, Liang Zhou, Dequan Yu, Lei Ping-sheng*,
Synthesis and Antitumor Activity of Icogenin and its Analogue
Bioorg.Med.Chem.Lett. 2006 16(9)
9. Shujie Hou, Chuanchun Zou, Pingsheng Lei*,
Synthesis of a group of Saponins via Orthogonal Protection-deprotection Glycosylation Chem.Lett.(JP) 2006 35(1) 84
10. Hou shu jie Hou, Chuanchun Zou, Pingsheng Lei*, Dequan Yu,
Facile Synthesis of Ophipogonin C’ and its Three Analogues
Chinese Chemical Letters, 2005, 16(11),
11. Shujie Hou, Chuanchun Zou, Pingsheng Lei*, Dequan Yu,
An Efficient Way for Glycosylation of Spirostanol,
Chinese Chemical Letters, 2005, 16(5)
12. Shujie Hou, Chuanchun Zou, Pingsheng Lei*, Dequan Yu,
Facile Synthesis of Dioscin and Analogues
Chem.Lett., （JP） 2005, 34(9)
13. Shujie Hou, Chuanchun Zou, Pingsheng Lei*, Dequan Yu,
Synthesis of Tigogenyl 2-Deoxy-2-phthalimido-D-glucopyranoside Derivatives and Study of their 1H-NMR Spectrum,
Chinese Chemical Letters, 2004, 15
14. Zou Chuan-chun, Hou Shu-jie, Shi Yang, Lei Ping-sheng*and Liang Xiao-tian.
The synthesis of gracillin and dioscin:two typical representatives of spirostanol glycosides Carbohydr. Res., 2003, 338: 721-727.
15. Zou Chuan-chun, Lei Ping-sheng* and Liang Xiao-tian
The synthesis of gracillin and dioscin:two typical representatives of spirostanol glycosides Chinese Chem. Lett., 2003, 14(4)
16. Villeneuve, S., Souchon, H., Riotto, M. M., Mazie, J. C., Lei, P. S., Glaudemans, C. P. J., Kovac, P., Fourner, J. M.,
Crystal structure of an anti-carbohydrate antibody directed against Vibrio Cholerae O:1 in complex with antigen: Molecular basis for serotype specificity
Proc.Natl.Acad.Sci., 2000